diff --git a/compiler/rustc_hir_typeck/src/fn_ctxt/suggestions.rs b/compiler/rustc_hir_typeck/src/fn_ctxt/suggestions.rs
index 2345cdab208e3..c4486818791d2 100644
--- a/compiler/rustc_hir_typeck/src/fn_ctxt/suggestions.rs
+++ b/compiler/rustc_hir_typeck/src/fn_ctxt/suggestions.rs
@@ -3539,15 +3539,25 @@ impl<'a, 'tcx> FnCtxt<'a, 'tcx> {
                 .must_apply_modulo_regions()
         {
             let sm = self.tcx.sess.source_map();
-            if let Ok(rhs_snippet) = sm.span_to_snippet(rhs_expr.span)
-                && let Ok(lhs_snippet) = sm.span_to_snippet(lhs_expr.span)
+            // If the span of rhs_expr or lhs_expr is in an external macro,
+            // we should find the user-written code span. See issue #139050
+            if let Some(rhs_span) = rhs_expr.span.find_ancestor_not_from_extern_macro(sm)
+                && let Some(lhs_span) = lhs_expr.span.find_ancestor_not_from_extern_macro(sm)
+                && let Ok(rhs_snippet) = sm.span_to_snippet(rhs_span)
+                && let Ok(lhs_snippet) = sm.span_to_snippet(lhs_span)
             {
                 err.note(format!("`{rhs_ty}` implements `PartialEq<{lhs_ty}>`"));
-                err.multipart_suggestion(
-                    "consider swapping the equality",
-                    vec![(lhs_expr.span, rhs_snippet), (rhs_expr.span, lhs_snippet)],
-                    Applicability::MaybeIncorrect,
-                );
+                if rhs_span != lhs_span {
+                    err.multipart_suggestion(
+                        "consider swapping the equality",
+                        vec![(lhs_span, rhs_snippet), (rhs_span, lhs_snippet)],
+                        Applicability::MaybeIncorrect,
+                    );
+                } else {
+                    // rhs_span and lhs_span are the same because it from extern macro.
+                    // we should suggest to swap two arguments of the equality
+                    err.span_help(rhs_span, "consider swapping two arguments of the equality");
+                }
             }
         }
     }
diff --git a/tests/ui/typeck/auxiliary/extern-macro-issue-139050.rs b/tests/ui/typeck/auxiliary/extern-macro-issue-139050.rs
new file mode 100644
index 0000000000000..9e20c86adabce
--- /dev/null
+++ b/tests/ui/typeck/auxiliary/extern-macro-issue-139050.rs
@@ -0,0 +1,15 @@
+#[macro_export]
+macro_rules! eq {
+    (assert $a:expr, $b:expr) => {
+        match (&$a, &$b) {
+            (left_val, right_val) => {
+                if !(*left_val == *right_val) {
+                    panic!(
+                        "assertion failed: `(left == right)`\n  left: `{:?}`,\n right: `{:?}`",
+                        left_val, right_val
+                    );
+                }
+            }
+        }
+    };
+}
diff --git a/tests/ui/typeck/sugg-swap-equality-in-macro-issue-139050.rs b/tests/ui/typeck/sugg-swap-equality-in-macro-issue-139050.rs
new file mode 100644
index 0000000000000..e7dfd41944ae1
--- /dev/null
+++ b/tests/ui/typeck/sugg-swap-equality-in-macro-issue-139050.rs
@@ -0,0 +1,33 @@
+// if we use lhs == rhs in a macro, we should not suggest to swap the equality
+// because the origin span of lhs and rhs can not be found. See issue #139050
+
+//@ aux-build:extern-macro-issue-139050.rs
+//@ aux-crate:ext=extern-macro-issue-139050.rs
+
+extern crate ext;
+
+use std::fmt::Debug;
+
+macro_rules! eq_local {
+    (assert $a:expr, $b:expr) => {
+        match (&$a, &$b) {
+            (left_val, right_val) => {
+                if !(*left_val == *right_val) { //~ ERROR  mismatched types [E0308]
+                    panic!(
+                        "assertion failed: `(left == right)`\n  left: `{:?}`,\n right: `{:?}`",
+                        left_val, right_val
+                    );
+                }
+            }
+        }
+    };
+}
+
+pub fn foo<I: Iterator>(mut iter: I, value: &I::Item)
+where
+    Item: Eq + Debug, //~ ERROR cannot find type `Item` in this scope [E0412]
+{
+    ext::eq!(assert iter.next(), Some(value)); //~ ERROR  mismatched types [E0308]
+    eq_local!(assert iter.next(), Some(value));
+}
+fn main() {}
diff --git a/tests/ui/typeck/sugg-swap-equality-in-macro-issue-139050.stderr b/tests/ui/typeck/sugg-swap-equality-in-macro-issue-139050.stderr
new file mode 100644
index 0000000000000..c53bbd846f33a
--- /dev/null
+++ b/tests/ui/typeck/sugg-swap-equality-in-macro-issue-139050.stderr
@@ -0,0 +1,45 @@
+error[E0412]: cannot find type `Item` in this scope
+  --> $DIR/sugg-swap-equality-in-macro-issue-139050.rs:28:5
+   |
+LL |     Item: Eq + Debug,
+   |     ^^^^ not found in this scope
+
+error[E0308]: mismatched types
+  --> $DIR/sugg-swap-equality-in-macro-issue-139050.rs:30:5
+   |
+LL |     ext::eq!(assert iter.next(), Some(value));
+   |     ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ expected `Option<<I as Iterator>::Item>`, found `Option<&<I as Iterator>::Item>`
+   |
+   = note: expected enum `Option<_>`
+              found enum `Option<&_>`
+   = note: `Option<&<I as Iterator>::Item>` implements `PartialEq<Option<<I as Iterator>::Item>>`
+help: consider swapping two arguments of the equality
+  --> $DIR/sugg-swap-equality-in-macro-issue-139050.rs:30:5
+   |
+LL |     ext::eq!(assert iter.next(), Some(value));
+   |     ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
+   = note: this error originates in the macro `ext::eq` (in Nightly builds, run with -Z macro-backtrace for more info)
+
+error[E0308]: mismatched types
+  --> $DIR/sugg-swap-equality-in-macro-issue-139050.rs:15:35
+   |
+LL |                 if !(*left_val == *right_val) {
+   |                                   ^^^^^^^^^^ expected `Option<<I as Iterator>::Item>`, found `Option<&<I as Iterator>::Item>`
+...
+LL |     eq_local!(assert iter.next(), Some(value)); 
+   |     ------------------------------------------ in this macro invocation
+   |
+   = note: expected enum `Option<_>`
+              found enum `Option<&_>`
+   = note: `Option<&<I as Iterator>::Item>` implements `PartialEq<Option<<I as Iterator>::Item>>`
+   = note: this error originates in the macro `eq_local` (in Nightly builds, run with -Z macro-backtrace for more info)
+help: consider swapping the equality
+   |
+LL -                 if !(*left_val == *right_val) {
+LL +                 if !(*right_val == *left_val) {
+   |
+
+error: aborting due to 3 previous errors
+
+Some errors have detailed explanations: E0308, E0412.
+For more information about an error, try `rustc --explain E0308`.