diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 9977332..96c536d 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -92,7 +92,7 @@ jobs:
       matrix:
         # When updating this, the reminder to update the minimum supported
         # Rust version in Cargo.toml.
-        rust: ['1.46']
+        rust: ['1.48']
     steps:
       - uses: actions/checkout@v3
       - name: Install Rust
diff --git a/Cargo.toml b/Cargo.toml
index e747ebd..1dfb5cf 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -6,7 +6,7 @@ name = "async-io"
 version = "1.12.0"
 authors = ["Stjepan Glavina <stjepang@gmail.com>"]
 edition = "2018"
-rust-version = "1.46"
+rust-version = "1.48"
 description = "Async I/O and timers"
 license = "Apache-2.0 OR MIT"
 repository = "https://github.com/smol-rs/async-io"
@@ -25,6 +25,7 @@ futures-lite = "1.11.0"
 log = "0.4.11"
 parking = "2.0.0"
 polling = "2.0.0"
+rustix = { version = "0.36.0", default-features = false, features = ["std", "fs"] }
 slab = "0.4.2"
 socket2 = { version = "0.4.2", features = ["all"] }
 waker-fn = "1.1.0"
@@ -32,12 +33,6 @@ waker-fn = "1.1.0"
 [build-dependencies]
 autocfg = "1"
 
-[target."cfg(unix)".dependencies]
-libc = "0.2.77"
-
-[target.'cfg(windows)'.dependencies]
-windows-sys = { version = "0.42", features = ["Win32_Networking_WinSock"] }
-
 [dev-dependencies]
 async-channel = "1"
 async-net = "1"
@@ -49,7 +44,6 @@ tempfile = "3"
 
 [target.'cfg(target_os = "linux")'.dev-dependencies]
 inotify = { version = "0.10", default-features = false }
-nix = { version = "0.25", default-features = false }
 timerfd = "1"
 
 [target.'cfg(windows)'.dev-dependencies]
diff --git a/examples/linux-timerfd.rs b/examples/linux-timerfd.rs
index e57053b..05ca38c 100644
--- a/examples/linux-timerfd.rs
+++ b/examples/linux-timerfd.rs
@@ -14,6 +14,7 @@ fn main() -> std::io::Result<()> {
 
     use async_io::Async;
     use futures_lite::future;
+    use rustix::fd::BorrowedFd;
     use timerfd::{SetTimeFlags, TimerFd, TimerState};
 
     /// Sleeps using an OS timer.
@@ -24,7 +25,14 @@ fn main() -> std::io::Result<()> {
 
         // When the OS timer fires, a 64-bit integer can be read from it.
         Async::new(timer)?
-            .read_with(|t| nix::unistd::read(t.as_raw_fd(), &mut [0u8; 8]).map_err(io::Error::from))
+            .read_with(|t| {
+                // Safety: We assume `as_raw_fd()` returns a valid fd. When we
+                // can depend on Rust >= 1.63, where `AsFd` is stabilized, and
+                // when `TimerFd` implements it, we can remove this unsafe and
+                // simplify this.
+                let fd = unsafe { BorrowedFd::borrow_raw(t.as_raw_fd()) };
+                rustix::io::read(fd, &mut [0u8; 8]).map_err(io::Error::from)
+            })
             .await?;
         Ok(())
     }
diff --git a/src/lib.rs b/src/lib.rs
index 0579e19..db6756b 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -598,21 +598,19 @@ impl<T: AsRawFd> Async<T> {
     /// # std::io::Result::Ok(()) });
     /// ```
     pub fn new(io: T) -> io::Result<Async<T>> {
-        let fd = io.as_raw_fd();
+        let raw = io.as_raw_fd();
 
         // Put the file descriptor in non-blocking mode.
-        unsafe {
-            let mut res = libc::fcntl(fd, libc::F_GETFL);
-            if res != -1 {
-                res = libc::fcntl(fd, libc::F_SETFL, res | libc::O_NONBLOCK);
-            }
-            if res == -1 {
-                return Err(io::Error::last_os_error());
-            }
-        }
+        //
+        // Safety: We assume `as_raw_fd()` returns a valid fd. When we can
+        // depend on Rust >= 1.63, where `AsFd` is stabilized, and when
+        // `TimerFd` implements it, we can remove this unsafe and simplify this.
+        let fd = unsafe { rustix::fd::BorrowedFd::borrow_raw(raw) };
+        let flags = rustix::fs::fcntl_getfl(fd)?;
+        rustix::fs::fcntl_setfl(fd, flags | rustix::fs::OFlags::NONBLOCK)?;
 
         Ok(Async {
-            source: Reactor::get().insert_io(fd)?,
+            source: Reactor::get().insert_io(raw)?,
             io: Some(io),
         })
     }
@@ -678,16 +676,14 @@ impl<T: AsRawSocket> Async<T> {
     /// ```
     pub fn new(io: T) -> io::Result<Async<T>> {
         let sock = io.as_raw_socket();
+        let borrowed = unsafe { rustix::fd::BorrowedFd::borrow_raw(sock) };
 
         // Put the socket in non-blocking mode.
-
-        use windows_sys::Win32::Networking::WinSock;
-
-        let mut nonblocking = true as _;
-        let res = unsafe { WinSock::ioctlsocket(sock as _, WinSock::FIONBIO, &mut nonblocking) };
-        if res != 0 {
-            return Err(io::Error::last_os_error());
-        }
+        //
+        // Safety: We assume `as_raw_socket()` returns a valid fd. When we can
+        // depend on Rust >= 1.63, where `AsFd` is stabilized, and when
+        // `TimerFd` implements it, we can remove this unsafe and simplify this.
+        rustix::io::ioctl_fionbio(borrowed, true)?;
 
         Ok(Async {
             source: Reactor::get().insert_io(sock)?,
@@ -1895,7 +1891,7 @@ fn connect(addr: SockAddr, domain: Domain, protocol: Option<Protocol>) -> io::Re
     match socket.connect(&addr) {
         Ok(_) => {}
         #[cfg(unix)]
-        Err(err) if err.raw_os_error() == Some(libc::EINPROGRESS) => {}
+        Err(err) if err.raw_os_error() == Some(rustix::io::Errno::INPROGRESS.raw_os_error()) => {}
         Err(err) if err.kind() == io::ErrorKind::WouldBlock => {}
         Err(err) => return Err(err),
     }